摘要 :
One of the fundamental problems in the realm of peer-to-peer systems is that of determining their service capacities. In this paper we focus on P2P scalability issues and propose models to compute the achievable throughput under d...
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One of the fundamental problems in the realm of peer-to-peer systems is that of determining their service capacities. In this paper we focus on P2P scalability issues and propose models to compute the achievable throughput under distinct policies for selecting both peers and blocks. From these models, we obtain novel insights on the behavior of P2P swarming systems that motivate new mechanisms for publishers and peers to improve the overall performance. In particular, we obtain operational regions for swarm system. In addition, we show that system capacity significantly increases if publishers adopt the most deprived peer selection and peers reduce their service rates when they have all the file blocks but one. (C) 2019 Elsevier B.V. All rights reserved.
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摘要 :
Purpose: Pax-6 is a master regulator for eye and brain development. Previous studies including ours have shown that Pax-6 exists in 4 major isoforms. According to their sizes, they are named p48, p46, p43 and p32 with the correspo...
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Purpose: Pax-6 is a master regulator for eye and brain development. Previous studies including ours have shown that Pax-6 exists in 4 major isoforms. According to their sizes, they are named p48, p46, p43 and p32 with the corresponding molecular weight of 48, 46, 43 and 32 kd, respectively. While p48 and p46 is derived from alternative splicing, p32 Pax-6 is generated through an internal translation initiation site. As for 43 kd Pax-6, two resources have been reported. In bird, it was found that an alternative splicing can generate a p43 Pax-6. In human and mouse, we reported that the p43 kd Pax-6 is derived from sumoylation: addition of a 11 kd polypeptide SUMO1 into the p32 Pax-6 at the K91 residue. Whether other Pax-6 isoforms can be sumoylated or not remains to be explored.
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