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Transducin (beta)-like 1X related protein 1 (TBL1XR1/TBLR1) is an integral subunit of the NCoR (nuclear receptor corepressor) and SMRT (silencing mediator of retinoic acid and thyroid hormone receptors) repressor complexes. It is ...
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Transducin (beta)-like 1X related protein 1 (TBL1XR1/TBLR1) is an integral subunit of the NCoR (nuclear receptor corepressor) and SMRT (silencing mediator of retinoic acid and thyroid hormone receptors) repressor complexes. It is an evolutionally conserved protein that shares high similarity across all species. TBL1XR1 is essential for transcriptional repression mediated by unliganded nuclear receptors (NRs) and othe regulated transcription factors (TFs). However, it can also act as a transcription activator through the recruitment of the ubiquitin-conjugating/19S proteasome complex that mediates the exchange of corepressors for coactivators. TBL1XR1 is required for the activation of multiple intracellular signaling pathways. TBL1XR1 germline mutations and recurrent mutations are linked to intellectual disability. Upregulation of TBL1XR1 is observed in a variety of solid tumors, which is associated with advanced tumor stage, metastasis and poor prognosis. A variety of genomic alterations, such as translocation, deletion and mutation have been identified in many types of neoplasms. Loss of TBL1XR1 in B-lymphoblastic leukemia disrupts glucocorticoid receptor recruitment to chromatin and results in glucocorticoid resistance. However, the mechanisms of other types of genomic changes in tumorogenesis are still not clear. A pre-clinical study has shown that the disruption of the interaction between TBL1X and β-catenin using a small molecule can inhibit the growth of AML stem and blast cells both in vitro and in vivo. These findings shed light on the therapeutic potentials of targeting TBL1XR1 related proteins in cancer treatment.
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TBL is a wear-resistant special structural steel with boron as heavy plate that is normalized with thicknesses up to 100 mm (3.9 in.) made of fine-grained structural steel TBL.
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Transducin (β)-like 1 X-linked receptor 1(TBL1XR1) has been reported to be overexpressed in various human cancers, as well as contributing to carcinogenesis and progression. This synthetic analysis was performed to assess whether...
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Transducin (β)-like 1 X-linked receptor 1(TBL1XR1) has been reported to be overexpressed in various human cancers, as well as contributing to carcinogenesis and progression. This synthetic analysis was performed to assess whether TBL1XR1 protein could act as a potential prognostic molecular marker for human cancers. Several online databases (PubMed, Web of Science, Embase together with Wanfang and China National Knowledge Internet database) were retrieved to identify TBL1XR1-related publications. A total of ten studies with 1837 cancer patients were included in this meta-analysis. Hazard ratios (HR) with 95% confidence intervals (CI) were applied to assess the association between TBL1XR1 expression and cancer prognosis. Odds ratios (OR) were calculated to determine the relationship between TBL1XR1 expression and clinicopathological characteristics. The overall results revealed that the overexpression of TBL1XR1 was correlated with poorer overall survival (OS) (HR: 1.77, 95% CI: 1.49–2.06, p < 0.001) and worse disease-free survival (DFS) (HR: 1.51, 95% CI: 1.19–1.84, p < 0.001) in human solid cancers. Statistical significance for OS was also found in subgroup analysis stratified by the cancer type, analysis method and follow-up time. Furthermore, elevated TBL1XR1 was associated with unfavorable clinicopathological characteristics including tumor size, depth of invasion, lymph node metastasis and TNM stage. Our meta-analysis suggested that TBL1XR1 might be served as a novel and promising biomarker to predict prognosis and clinicopathologic characteristic for cancer patients.
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We introduced two variants of team based learning (TBL) strategies in pathology course to seek their efficacy in a problem based learning (PBL) curriculum. The TBL strategy was adopted in two different sessions. One during regular...
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We introduced two variants of team based learning (TBL) strategies in pathology course to seek their efficacy in a problem based learning (PBL) curriculum. The TBL strategy was adopted in two different sessions. One during regular resource session (RS-TBL) and other during a weekly review session (RVS-TBL) of the PBL curriculum. The study involved 104 second year students during their 8 weeks of cardiovascular-respiratory units and 3 weeks of hematology units. RS-TBL was adopted for cardiovascular-respiratory unit and RVS-TBL for hematology unit. The first 8 weeks of the course were implemented as RS-TBL and the last 3 weeks as RVS-TBL. The results showed that the group performance was markedly improved than individual performance in both RS-TBL and RVS-TBL (p < 0.001). Comparison between the RS-TBL and RVS-TBL revealed that individual student and group performance was better in the RVS-BL (p < 0.001). The result of the student attitudinal survey indicated an 88% agreement that TBL enhanced their understanding of pathology concepts and critical analysis. Most of the participants (85%) found RVS-TBL to be more useful. Post-TBL, end of semester examination results proved beneficial for the students in risk. The study demonstrated that RVS-TBL may be preferably adopted to enhance the philosophy of TBL in a PBL curriculum.
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It seems like every manufacturer in the world is making a powered speaker-on-a-stick solution these days, and many of them really do the trick for portable sound reinforcement. But there are certain applications for which a pair o...
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It seems like every manufacturer in the world is making a powered speaker-on-a-stick solution these days, and many of them really do the trick for portable sound reinforcement. But there are certain applications for which a pair of plastic potato-shaped boxes just won't do the trick. And sure, you could get into stacks of boxes in order to achieve high quality, but then portability suffers. Is there a middle-of-the-road solution? There is indeed. The JBL Professional VRX series loudspeakers have been available for a couple of years, and the company has recently introduced powered versions of this series, further enhancing portability. I test-drove a system consisting of two VRX918SP subwoofers, each supporting two VRX932LAP boxes. Frankly, I was thrilled. The VRX932LAP is similar to other line-array loudspeakers, with one notable exception-we've grown accustomed to seeing symmetrical LF drivers on either side of the HF array in the middle of the box. Shave off one of those LF drivers, and you have the VRX932LAP.
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She applies the admonition equally to products and services, not caring whether the company is a building product manufacturer, commercial contractor or magazine publisher. The point is that companies who claim they make a green p...
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She applies the admonition equally to products and services, not caring whether the company is a building product manufacturer, commercial contractor or magazine publisher. The point is that companies who claim they make a green product can't truly assert that if the back end of the business is as brown as mud.
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Lawson-Hemphill of the TMI Group, New Castle, DE/USA, has aquired Textilbedarf Langen GmbH (TBL), Monchengladbach/Ger-many, a leading distributor of machines, accessories and testing equipment for the textile and yarn industries. ...
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Lawson-Hemphill of the TMI Group, New Castle, DE/USA, has aquired Textilbedarf Langen GmbH (TBL), Monchengladbach/Ger-many, a leading distributor of machines, accessories and testing equipment for the textile and yarn industries. TBL was established in 1935. For more than 30 years TBL was the agent of the TMI Lawson-Hemphill division for textile testing equipment with sales and service support for Central Europe.
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Xylan is one of the major polymers in lignocellulosic biomass and about 60% of its xylosyl residues are acetylated at O-2 and/or O-3. Because acetylation of cell wall polymers contributes to biomass recalcitrance for biofuel produ...
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Xylan is one of the major polymers in lignocellulosic biomass and about 60% of its xylosyl residues are acetylated at O-2 and/or O-3. Because acetylation of cell wall polymers contributes to biomass recalcitrance for biofuel production, it is important to investigate the biochemical mechanism underlying xylan acetylation, the knowledge of which could be applied to custom-design biomass composition tailored for biofuel production. In this report, we investigated the functions of Arabidopsis TRICHOME BIREFRINGENCE-LIKE 34 (TBL34) and TBL35, two DUF231-containing proteins, in xylan acetylation. The TBL34 gene was found to be specifically expressed in xylem cells in stems and root-hypocotyls, and both TBL34 and TBL35 were shown to be localized in the Golgi, where xylan biosynthesis occurs. Chemical analysis revealed that simultaneous mutations of TBL34 and TBL35 caused a mild decrease in xylan acetyl content and a specific reduction in xylan 3-O-monoacetylation and 2,3-di-O-acetylation. Furthermore, simultaneous mutations of TBL34, TBL35 and ESKIMO1 (ESK1) resulted in severely collapsed xylem vessels with altered secondary wall structure, and an extremely retarded plant growth. These findings indicate that TBL34 and TBL35 are putative acetyltransferases required for xylan 3-O-monoacetylation and 2,3-di-O-acetylation and that xylan acetylation is essential for normal secondary wall deposition and plant growth. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
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Transformation Based Learning (TBL) is a Machine Learning technique frequently used in some Natural Language Processing (NLP) tasks. TBL uses rule templates to identify error-correcting patterns. A critical requirement in TBL is t...
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Transformation Based Learning (TBL) is a Machine Learning technique frequently used in some Natural Language Processing (NLP) tasks. TBL uses rule templates to identify error-correcting patterns. A critical requirement in TBL is the availability of a problem domain expert to build these rule templates. In this work, we propose an evolutionary approach based on Genetic Algorithms to automatically implement the template generation process. Additionally, we report our findings on five experiments with useful NLP tasks. We observe that our approach provides template sets with a mean loss of performance of 0.5% when compared to human built templates
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