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Monitoring unsafe operations of construction machines is important for reducing accidents on sites. To automate safety monitoring, this paper studies pose estimation of construction machines, which describes their motions in 3D sp...
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Monitoring unsafe operations of construction machines is important for reducing accidents on sites. To automate safety monitoring, this paper studies pose estimation of construction machines, which describes their motions in 3D space. Inertial Measurement Unit (IMU) is considered accurate, cost-saving and user-friendly for estimating the pose of machines. Nevertheless, the complexity and instability of construction sites hinder the application of IMU to construction machines. Hence, this study first defines the information requirements of IMU-based full -body pose estimation for construction machines. Then, an efficient method is developed to generate the tra-jectories of a machine based on kinematics. Moreover, an optimal installation scheme for IMU sensors is investigated systematically to optimize the location and number of IMUs to install. Overall, this study contributes an IMU-based method to provide full-body poses of machines without environmental constraints on real con-struction sites, and a theoretical basis of optimal IMU installation strategy for reliable motion-related analyses.
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The variation of construction machine poses is one of the main causes for interactive on-site safety issues such as struck-by hazards. With the aim to reduce such hazards, we propose a framework for predicting construction machine...
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The variation of construction machine poses is one of the main causes for interactive on-site safety issues such as struck-by hazards. With the aim to reduce such hazards, we propose a framework for predicting construction machine poses based on historical motion data and activity attributes. After building a machine motion dataset, we develop a keypoint-based method for recognizing machine activities considering working patterns and interaction characteristics. The recognized activity information is then incorporated with historical pose data to predict future machine poses through a type of recurrent neural network (RNN), named Gated Recurrent Unit (GRU). In experiments of using excavators as the objects, our framework achieves decent performance for machine pose prediction, which is further improved by incorporating activity information, reaching an average percentage of correct keypoints (PCK) of 90.22%. The results indicate the high potential of our framework in predicting construction machine poses and improving on-site safety.
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The term textural complexity is associated with a range of different perceivable textures and sensations occurring from first bite through to swallow. The aim of this study was to develop gel-based model foods with "built-in" leve...
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The term textural complexity is associated with a range of different perceivable textures and sensations occurring from first bite through to swallow. The aim of this study was to develop gel-based model foods with "built-in" levels of textural complexity for use in a wider study of the impact of texture on satiation and satiety. The model foods needed to be quantified for textural complexity and that assessment was conducted using instrumental and sensory measurements model foods of different structural complexity (based on inclusions and layers with differing mechanical properties) resulted in puncture curves with differing numbers of peaks caused by the sequential puncture of structural features, and in differing lengths; in general higher complexity led to a greater number of peaks and greater length. Consistent with the definition of textural complexity, more texturally complex samples generated a greater number of descriptors during the "chewdown" phase in descriptive sensory analysis. Temporal dominance of sensation (TDS) analysis gave different information on the dynamics of texture perception during chewing sequence compared to descriptive analysis but confirmed the levels of textural complexity of the model foods. In particular TDS indicates the evolution of the number of texture attributes perceived, and the number of times the dominant texture changed.
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Background:Previous studies have investigated the relationship between GSTA1, GSTM1, GSTP1, and GSTT1 polymorphisms and bladder cancer (BCa) susceptibility, respectively, but the results remain inconsistent. So, we conducted this ...
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Background:Previous studies have investigated the relationship between GSTA1, GSTM1, GSTP1, and GSTT1 polymorphisms and bladder cancer (BCa) susceptibility, respectively, but the results remain inconsistent. So, we conducted this meta-analysis including 79 case-control studies to explore such relationships.Methods:We searched PubMed, EMBASE, Cochrane library, Web of Science, and CNKI for relevant available studies. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were implemented to evaluate the intensity of associations. Publication bias was estimated using Begg funnel plots and Egger regression test. To assess the stability of the results, we used sensitivity analysis with the method of calculating the results again by omitting 1 single study each time. Between-study heterogeneity was tested using the I-2 statistic.Results:No significant association between GSTA1 polymorphism and BCa susceptibility (OR=1.05, 95% CI 0.83-1.33) was noted. Besides, meaningful association between individuals who carried the GSTM1 null genotype and increased BCa risk was detected (OR=1.39, 95%CI 1.28-1.51). When stratified by ethnicity, significant difference was found in both Caucasian (OR=1.39, 95% CI 1.23-1.58) and Asian populations (OR=1.45, 95% CI 1.31-1.61). Moreover, in the subgroup analysis by source of controls (SOC), the results were significant in both hospital-based control groups (OR=1.49, 95% CI 1.35-1.64) and population-based control groups (OR=1.21, 95% CI=1.07-1.37). Additionally, the analysis revealed no significant association between GSTP1 polymorphism and BCa risk (OR=1.07, 95% CI 0.96-1.20). What is more, significant associations between GSTT1 polymorphism and BCa susceptibility were discovered (OR=1.11, 95% CI 1.00-1.22). In the subgroup analysis by ethnicity, significant associations between GSTT1 null genotype and BCa risk were observed only in Caucasians (OR=1.25, 95% CI 1.09-1.44). Furthermore, when stratified by SOC, no obvious relationship was found between the GSTT1 null genotype polymorphism with hospital-based population (OR=1.11, 95% CI 0.97-1.28) or population-based population (OR=1.10, 95% CI 0.96-1.27).Conclusion:This study suggested that GSTM1 null genotype and GSTT1 null genotype might be related to higher BCa risk, respectively. However, no associations were observed between GSTA1 or GSTP1 polymorphisms and BCa susceptibility.
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The aim of this study was to examine textural complexity by developing a model food with varying levels of textural complexity but comparable nutritional density. Embedding inclusions in a gel matrix and layering the samples creat...
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The aim of this study was to examine textural complexity by developing a model food with varying levels of textural complexity but comparable nutritional density. Embedding inclusions in a gel matrix and layering the samples created different levels of structural and textural complexity: low, medium, and high. Texture properties and textural complexity were analyzed by generic quantitative descriptive analysis and modified texture profiling. The total number of unique textural descriptors observed by the panellists was used as a rudimentary measure of textural complexity and an increasing trend of textural complexity, low complexity < medium complexity < high complexity was observed. Ten unique descriptors showed significantly greater intensity ratings (p < 0.05) for the high complexity sample. This suggested that these textural attributes may be more likely to be distinguished during consumption of a high complexity sample compared to the low complexity or medium complexity samples, leading to greater perceived textural complexity in the high complexity sample.
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The introduction of nano-sized BaTiO3 (BT) into polymer host matrices brings about promising dielectric and energy storage properties. However, pristine BT tends to aggregate and is difficult to be compatible with polymer matrices...
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The introduction of nano-sized BaTiO3 (BT) into polymer host matrices brings about promising dielectric and energy storage properties. However, pristine BT tends to aggregate and is difficult to be compatible with polymer matrices, thus requiring surface modification of BT nanoparticles. In this work, gamma-aminopropyl triethoxysilane (KH550) was grafted onto the surface of BT as a shell and amino-functionalized core-shell KH550@BT nanoparticles have been successfully prepared. Thereafter, poly(arylene ether nitrile) (PEN) has been chosen as polymer matrix due to its excellent thermal properties, and xKH550@BT/(1-x)PEN composite films were prepared by solution casting film formation method. The energy density of KH550@BTIPEN composites with 30 wt.% filler loading is 1.30 J cm(-3) (eta = 61.32 %) at 150 MV m(-1), more than 36.84 % increase when compared with pristine PEN polymer (0.95 J cm(-3) at 170 MV m(-1)). Temperature-dependent and frequency-dependent D-E loops confirmed that KH550@BTIPEN composites possess good temperature and frequency stability. (C) 2020 Elsevier B.V. All rights reserved.
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Growing evidences demonstrate that long non-coding RNAs (lncRNAs) contribute to the cancer initiation and progression and are considered as promising diagnostic and therapeutic targets of multiple cancers. However, the definite ro...
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Growing evidences demonstrate that long non-coding RNAs (lncRNAs) contribute to the cancer initiation and progression and are considered as promising diagnostic and therapeutic targets of multiple cancers. However, the definite role of LINC00536 in bladder cancer (BC) remains unclear. In the present study, we found LINC00536 expression was highly expressed in BC tissues compared with controls and negatively associated with survival rate in BC patients. Gain-of-function assays indicated that LINC00536 overexpression promoted the proliferation, migration and invasion, whereas LINC00536 knockdown attenuated the cell phenotypes above in BC cell lines. In vivo assay illustrated that LINC00536 knockdown inhibited BC growth in vivo. Mechanistically, Wnt3a was identified as the target of LINC00536. LINC00536 promoted malignant phenotypes via activating the Wnt3a/beta-Catenin signaling. Wnt3a knockdown reversed the increase of proliferation, migration, and invasion abilities of BC cells induced by LINC00536 overexpression. In summary, our findings demonstrated that LINC00536 promoted BC progression by modulating the Wnt3a/beta-Catenin signaling.
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Lenvatinib is an oral, multi-targeted tyrosine kinase inhibitor of vascular endothelial growth factor receptors 1-3, fibroblast growth factor receptors 1-4, platelet-derived growth factor receptor beta, RET and KIT. Cellular immun...
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Lenvatinib is an oral, multi-targeted tyrosine kinase inhibitor of vascular endothelial growth factor receptors 1-3, fibroblast growth factor receptors 1-4, platelet-derived growth factor receptor beta, RET and KIT. Cellular immunotherapy has the potential to be a highly targeted treatment, with low toxicity to normal tissues and a high capacity to eradicate tumor tissue. The present study assessed the safety, maximum tolerated dose (MTD) and preliminary antitumor activity of lenvatinib and cellular immunotherapy in a murine model of renal cell carcinoma (RCC). The present study used a therapeutic dose of 0.12 mg lenvatinib and/ or 10(4) rat uterine cancer adenocarcinoma (RuCa)-sensitized lymphocytes administered once daily continuously in 7-day cycles. Tumor regression was observed in mice with RCC following treatment with lenvatinib and 10(4) RuCa-sensitized lymphocytes. MTD was established as once daily administration of 0.18 mg lenvatinib and 10(6) RuCa-sensitized lymphocytes. The most common treatment-related adverse effects observed were fatigue (40%), mucosal inflammation (30%), proteinuria, diarrhea, vomiting, hypertension and nausea (all 40%). Combination therapy using lenvatinib and cellular immunotherapy enhanced the antitumor effect induced by single treatments and prolonged the survival of mice with RCC compared with either of the single treatments. Treatment with lenvatinib (0.12 mg) combined with 104 RuCa-sensitized lymphocytes was associated with manageable toxicity consistent with individual agents. Further evaluation of this combination therapy in mice with advanced RCC is required. In conclusion, cellular immunotherapy and oncolytic therapy for cancer may be improved by the synergistic effects of lenvatinib and sensitized lymphocytes. In the present study, the inherent antineoplastic and immune stimulatory properties of the two agents were enhanced when used in combination, which may provide a basis for clinical treatment of patients with RCC.
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Background:Recently, increasing relevant studies researched the efficacy of castration resistant prostate cancer (CRPC) patients using chemotherapy with or without estramustine, in order to assess the efficacy and toxicity of comb...
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Background:Recently, increasing relevant studies researched the efficacy of castration resistant prostate cancer (CRPC) patients using chemotherapy with or without estramustine, in order to assess the efficacy and toxicity of combining estramustine with chemotherapy for the treatment of CRPC.Methods:Relevant randomized clinical trials were systematically searched from the databases Pubmed, Embase, and Web of science up to April 1, 2016. Data were centrally extracted and analyzed from the previous studies by 2 independent reviewers. The primary endpoint was overall survival (OS) with pooled hazard ratios. Secondary endpoints were prostate-specific antigen (PSA) response and grade 3 or 4 toxicity using pooled odds ratios. Stata version 12.0 software was used for statistical analysis.Results:Overall, this meta-analysis identified 9 eligible articles, including a total of 956 patients, who had been accrued between January 1, 1993 and December 1, 2010 and randomly divided into chemotherapy with estramustine and without estramustine. Chemotherapy (with or without estramustine) consisted of docetaxel, paclitaxel, ixabepilone, epirubicin, and vinblastine. Patients who received chemotherapy with estramustine had a better improvement in PSA response rate, comparing those without estramustine (OR = 1.84, 95% CI = 1.20-2.80). However, OS between the 2 groups indicated no significant differences (HR = 0.90, 95% CI = 0.77-1.05). Besides, these results of meta-analysis showed no obvious differences between these 2 groups in grade 3 or 4 adverse effects, including anemia (OR = 0.78, 95% CI = 0.38-1.57), neutropenia (OR = 0.91, 95% CI = 0.59-1.43), thrombocytopenia (OR = 0.68, 95% CI = 0.19-2.42), nausea (OR = 2.34, 95% CI = 0.81-6.72), vomiting (OR = 2.43, 95% CI = 0.69-8.51), diarrhea (OR = 3.45, 95% CI = 0.93-12.76), fatigue (OR = 0.67, 95% CI = 0.32-1.41), neuropathy (OR = 0.54, 95% CI = 0.21-1.44), allergic reaction (OR = 1.60, 95% CI = 0.37-6.84), thromboembolic event (OR = 2.18, 95% CI = 0.86-5.51), and edema (OR = 1.02, 95% CI = 0.18-5.95).Conclusions:This meta-analysis indicated chemotherapy with additional estramustine increased the PSA response rate. However, OS and grade 3 or 4 toxicity were not improved for these patients with CRPC.
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Previous studies have shown that food texture affects satiation by influencing the eating rate, bite size and oral transit time. However, investigations into the direct effect of texture on satiation are limited. The objective of ...
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Previous studies have shown that food texture affects satiation by influencing the eating rate, bite size and oral transit time. However, investigations into the direct effect of texture on satiation are limited. The objective of the current study was to investigate the effect of textural complexity on satiation, independent of oral processing time and energy density. A preload-test meal design was used in this study; model foods with three levels of textural complexity (low, medium and high) were consumed as preload foods followed by a two-course ad libitum meal. This study was a randomized cross-over trial with 38 subjects. The results clearly showed that food with greater textural complexity led to significantly lower food intake overall. The first course of the meal and total food intake was significantly reduced (p < 0.05) although food intake at the second course did not differ between groups. Despite the differing total intake, all subjects rated to have the same sense of satiety after three hours post-trial and the time taken to the next eating occasion did not differ between different preload conditions. Increased textural complexity in food enhances satiation and may potentially impact on satiety however this needs to be further confirmed in future studies. The findings suggest that foods with more complex textures can be a helpful tool in reducing the short-term food intake and enhancing the satiation response. (C) 2016 Elsevier Inc. All rights reserved.
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