摘要 :
Organizations arc increasingly evolving their workplace climate to accommodate the youngest generation with millennials slowly taking over leadership positions. Millennials have transformed the way businesses interact with workers...
展开
Organizations arc increasingly evolving their workplace climate to accommodate the youngest generation with millennials slowly taking over leadership positions. Millennials have transformed the way businesses interact with workers by sheer force of numbers. India has one of the youngest demographics in the world, with post-millennials also starting to join the workforce. Studies have shown that millennials are different from the earlier generations in their work attributes. Some of their workplace expectations collide with the conventional workplace norms; yet many organizations have started to reshape their workplace strategies to provide more opportunities to the millennials. The COVID-19 pandemic pushed a Fast Forward button to these efforts and 2020 saw almost all the businesses promptly changing their working norms. Remote working, along with digital technology and flexi-hours - once characterized as the millennial work characteristics - became the new normal for everyone. Retaining tech-savvy employees has become a significant concern of business, and they are fighting for the best talent to overtake the now aging Gen X employees. As new ground realities of remote working hit us, this research seeks to gain an insight into the minds of senior-level managers who are facing the new class of workers. This study is an attempt to fulfil this gap in the industry and facilitate a more relatable work environment for the millennials.
收起
摘要 :
In the present paper we investigate the sufficiency conditions for which a normalized Hurwitz-Lerch Zeta function is convex in the open unit disk. A similar property as well as properties of close-to-convexity and starlikeness of ...
展开
In the present paper we investigate the sufficiency conditions for which a normalized Hurwitz-Lerch Zeta function is convex in the open unit disk. A similar property as well as properties of close-to-convexity and starlikeness of a normalized Mittag-Leffler are also studied. The concluding section gives some examples which are deduced from the main results and for such special cases we also employ certain numerically set values for the parameters in order to find their image domains under the unit disk.
收起
摘要 :
Helicobacter pylori infection has been significantly linked to Peptic Ulcer Disease and Gastric Cancer. Metabolomic fingerprinting may offer a principal way of early diagnosis and to understand the molecular mechanism of H. pylori...
展开
Helicobacter pylori infection has been significantly linked to Peptic Ulcer Disease and Gastric Cancer. Metabolomic fingerprinting may offer a principal way of early diagnosis and to understand the molecular mechanism of H. pylori -induced pathogenicity. The rationale of the study is to explore the underlying distinct metabolic mechanisms of H. pylori-induced PUD and to identify potential biomarkers for disease diagnosis and associated risks using Gas chromatography/mass spectrometry. GC/MS-based analytical method was used to compare metabolic profiles of healthy controls (N = 20) and peptic ulcer patients (N = 45). Acquired metabolomic data were analyzed by constructing a diagnostic model using principal component analysis and a non-parametric two-tailed paired Wilcoxon analysis to identify disease-specific metabolic biomarkers. A total of 75 low-molecular-weight endogenous metabolites were detected during comparative metabolomic analysis of PUD vs. healthy gut tissues, among which 16 metabolites are being proposed to be diagnostic markers of Human PUD. Perturbations related to amino acids, carbohydrates, fatty acids, organic acids, and sterol metabolism were significantly revealed during this differential metabolomic profiling. Results convincingly suggest that metabolic profiles can contribute immensely in early diagnosis of the disease and understanding molecular mechanisms of disease progression for predicting novel drug targets for prophylactic and anaphylactic measures.
收起
摘要 :
Halogen-bonding interactions in electron-deficient π scaffolds have largely been underexplored. Herein, the halogen- bonding properties of arylene imide/diimide-based electron-deficient scaffolds were studied. The influence of sc...
展开
Halogen-bonding interactions in electron-deficient π scaffolds have largely been underexplored. Herein, the halogen- bonding properties of arylene imide/diimide-based electron-deficient scaffolds were studied. The influence of scaffold size, from small (phthalimide) to moderately sized (pyromellitic diimide or naphthalenediimides) to large (perylenediimide), axial-group modification, and number of halo substituents on the halogen bonding and its self-assembly was probed in a set of nine compounds. The structural modification leads to tunable optical and redox properties. The first reduction potential E_(1/2)~1 ranges between -1.09 and -0.17 V (vs. SCE). Two of the compounds, that is, 6 and 9, have deep-lying LUMOs with values reaching -4.2 eV. Single crystals of all nine systems were obtained, which showed Br···O, Br···Br, or Br···π halogen-bonding interactions, and a few systems are capable of forming all three types. These interactions lead to halogen-bonded rings (up to 12-membered), which propagate to form stacked 1D, 2D, or corrugated sheets. A few outliers were also identified, for example, molecules that prefer C-H···O hydrogen bonding over halogen bonding, or noncentrosymmetric rather than centrosymmetric organization. Computational studies based on Atoms in Molecules and Natural Bond Orbital analysis provided further insight into the halogen-bonding interactions. This study can lead to a predictive design tool-box to further explore related systems on surfaces reinforced by these weak directional forces.
收起
摘要 :
??In the present paper, we investigate certain geometric properties and inequalities for the Wright function and mention a few important consequences of our main results. A nonlinear differential equation involving the Wright func...
展开
??In the present paper, we investigate certain geometric properties and inequalities for the Wright function and mention a few important consequences of our main results. A nonlinear differential equation involving the Wright function is also investigated.
收起
摘要 :
Abstract For the first time, the simultaneous synthesis and deposition of heterometallic porphyrin conjugated polymer thin films from a simple and scalable gas‐phase approach are reported. The oxidative chemical vapor deposition ...
展开
Abstract For the first time, the simultaneous synthesis and deposition of heterometallic porphyrin conjugated polymer thin films from a simple and scalable gas‐phase approach are reported. The oxidative chemical vapor deposition (oCVD) reaction of 5,15‐(diaryl) porphyrins chelated with different metal cations (M = Co(II), Ni(II), Zn(II), Cu(II), Pd(II)) readily yields the formation of new hetero‐metalated fused porphyrin tapes, such as evidenced by in‐depth high‐resolution mass spectrometry studies. The impact of the coreactants on the regioselectivity of the intermolecular dehydrogenative coupling reaction and the formation of double or triple bonds between the porphyrin units is demonstrated. The oCVD reaction of multiple porphyrins brings the possibility to easily engineer the chemical features and the electronic and optoelectronic properties of these highly conjugated porphyrin polymers. Particularly, it is demonstrated that porphyrin conjugated polymers having different chelated metal cations can achieve higher electrical conductivities and promote narrower bandgaps. The gas‐phase approach presented herein overcomes the main limitations of the conventional solution‐based approaches and opens the path to the engineering of a novel class donor–acceptor heterometallic polymers with high interest in several fields including multimetallic electrocatalysis, photocatalysis, sensing, and nonlinear optics applications.
收起
摘要 :
Thin films of cobalt porphyrin conjugated polymers bearing different substituents are prepared by oxidative chemical vapor deposition (oCVD) and investigated as heterogeneous electrocatalysts for the oxygen evolution reaction (OER...
展开
Thin films of cobalt porphyrin conjugated polymers bearing different substituents are prepared by oxidative chemical vapor deposition (oCVD) and investigated as heterogeneous electrocatalysts for the oxygen evolution reaction (OER). Interestingly, the electrocatalytic activity originates from polymer- derived, highly transparent Co(Fe)Ox species formed under operational alkaline conditions. Structural, compositional, elec- trical, and electrochemical characterizations reveal that the newly formed active catalyst greatly benefited from both the polymeric conformation of the porphyrin-based thin film and the inclusion of the iron-based species originating from the oCVD reaction. High- resolution mass spectrometry analyses combined with density functional theory (DFT) calculations showed that a close relationship exists between the porphyrin substituent, the extension of the π-conjugated system cobalt porphyrin conjugated polymer, and the dynamics of the polymer conversion leading to catalytically active Co(Fe)Ox species. This work evidences the precatalytic role of cobalt porphyrin conjugated polymers and uncovers the benefit of extended π-conjugation of the molecular matrix and iron inclusion on the formation and performance of the true active catalyst.
收起
摘要 :
Abstract Background Access to intra‐arterial chemotherapy for retinoblastoma in low‐ and middle‐income countries (LMICs) is limited. There is a need to optimize the efficacy of systemic chemotherapy for advanced intraocular ret...
展开
Abstract Background Access to intra‐arterial chemotherapy for retinoblastoma in low‐ and middle‐income countries (LMICs) is limited. There is a need to optimize the efficacy of systemic chemotherapy for advanced intraocular retinoblastoma, particularly in LMICs. The aim was to compare the efficacy of standard versus higher dose carboplatin‐based intravenous chemotherapy for group D and E retinoblastoma. Methods The single‐center, single‐blinded, randomized study was conducted during 2019–2021. Patients with newly diagnosed group D or E retinoblastoma were randomized to receive vincristine, etoposide, and standard versus higher dose (<36?months: 18.6 vs. 28?mg/kg; ≥36?months: 560 vs. 840?mg/m2) carboplatin. Examination under anesthesia and ultrasonography was performed at diagnosis and following three cycles of chemotherapy. Group E eyes with poor likelihood of globe/vision salvage at diagnosis were excluded. Results Thirty‐two eyes of 30 patients were analyzed: 17 group D and 15 group E eyes. The tumor response to chemotherapy with regards to regression pattern (p?=?.72), tumor shrinkage (diameter: p?=?.11, height: p?=?.96), subretinal seeds (p?=?.91), and vitreous seeds (p?=?.9) were comparable between the two treatment arms. The globe salvage (group D [82% vs. 67%; p?=?.58]; group E [12.5% vs. 29%; p?=?.57]) and salvage of meaningful vision (group D [100% vs. 75%; p?=?.13]; group E [100% vs. 50%; p?=?.48]) were comparable between standard and higher dose arms. No excess treatment‐related toxicity was observed in the higher dose arm. Conclusions Higher dose carboplatin‐based intravenous chemotherapy did not result in superior globe or vision salvage in group D or E retinoblastoma.
收起
摘要 :
There has been a good deal of discussion over the most sustainable model for development of housing in India. Planners discuss the advantages of low-rise versus high-rise development in terms of energy and cost efficiency. Shortag...
展开
There has been a good deal of discussion over the most sustainable model for development of housing in India. Planners discuss the advantages of low-rise versus high-rise development in terms of energy and cost efficiency. Shortage and high cost of land has been a justification for high-rise development. In this paper, mixed housing (EWS, LIG, MIG, and HIG), from 1 to 30 stories, has been analyzed at a city level for a fixed population for embodied energy, construction cost, and potential for CO_(2e) sequestration. The inference drawn from this exercise is that low-rise (1-4 stories) load-bearing development is energy and cost efficient and can accommodate the maximum number of housing units in about 4% of the land area in a city. High-rise development is 194% and 17.5% more than low-rise in terms of embodied energy and construction cost, respectively. It is also found that 100% of CO_(2e) can be sequestered by planting trees in available open areas in low-rise developments compared with 57% in high-rise development (30-story). Further, high-rise development results in only marginal increase in open areas after four stories. Hence, high-rise development is neither sustainable nor cost effective.
收起
摘要 :
Embodied energy and cost of construction of any building depends upon the consumption of resources, more specifically construction materials. In housing clusters, the spaces provided for horizontal and vertical circulation of occu...
展开
Embodied energy and cost of construction of any building depends upon the consumption of resources, more specifically construction materials. In housing clusters, the spaces provided for horizontal and vertical circulation of occupants such as corridors and contribute in the built-up area of individual unit without any increase in the usable/carpet area. Thus, an efficient architectural planning of common circulation spaces plays a major role in lowering the built-up-to-carpet area ratio of individual housing unit in clusters. This may, thus, result in lesser embodied energy and maximum area availability for occupant usage. In the present study, 30 clusters of Indian affordable housing units (IAHUs) of similar typology and different architectural designs are analyzed. The built-up and carpet area of each IAHU are estimated, and the ratio of the built-up to carpet area is calculated. Detailed estimates of construction materials for each IAHU is prepared, and cost of construction and embodied energy is calculated. The calculations of embodied energy and construction cost are done for major construction materials, viz., cement, steel, bricks, sand, and coarse aggregate and compared with different built-up-to-carpet area ratio. The study of IAHUs concludes that a variation of 1.30 to 1.62 in the built-up area-to-carpet area ratio results in variation in construction cost (INR 13,425.00 to 20,138.00 per m<sup>2</sup> carpet area) and embodied energy (4–6.5?GJ per m<sup>2</sup> carpet area). Analysis suggests that the IAHU with a lower built-up-to-carpet area ratio exhibits reduction in the cost of construction and embodied energy simultaneously. Thus, an efficient architectural design plays a major role in improving the sustainability of IAHUs and built-up-to-carpet area ratio is an important indicator of sustainability.
收起
原文获取