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Approximately 24,000 liver transplants are performed annually worldwide, almost 7000 of which are performed in the USA. Survival is excellent and continues to improve, with 1-year survival currently exceeding 85 %, but effective m...
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Approximately 24,000 liver transplants are performed annually worldwide, almost 7000 of which are performed in the USA. Survival is excellent and continues to improve, with 1-year survival currently exceeding 85 %, but effective management of patients after liver transplantation is critical to achieve optimal results. A plethora of diseases can affect the transplanted allograft, ranging from recurrence of the original disease to de novo liver pathology, and diagnosis can be complicated by nonclassical presentation, de novo disease, or inconclusive histology. Patients can remain asymptomatic despite significant damage to the transplanted liver, so prompt identification and treatment of liver disease after transplantation is crucial to preserve allograft function. Liver function tests are routinely taken throughout the postoperative period to monitor the graft. Although nonspecific, they are inexpensive, noninvasive, and sensitive for allograft disease and can quickly alert physicians to the presence of asymptomatic pathology. This review will outline possible causes of liver function test abnormalities in the late posttransplant period and provide guidance for investigation, diagnosis, and management.
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Objective: To assess the association of preeclampsia with deranged liver enzymes of patients presenting in a tertiary care hospital. Methods: It was case a control study including 100 females who fulfilled the inclusion criteria. ...
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Objective: To assess the association of preeclampsia with deranged liver enzymes of patients presenting in a tertiary care hospital. Methods: It was case a control study including 100 females who fulfilled the inclusion criteria. They were enrolled in the study from OPD of Department of Obstetrics and Gynecology, Ghurki Trust Teaching Hospital, Lahore. Informed consent was obtained. Then two groups were formed i.e. cases with preeclampsia and controls without preeclampsia. Then blood sample was obtained in 3cc BD syringe. All samples were sent to the laboratory of the hospital for assessment of ALT and AST. Data was entered and analyzed by SPSS version 21.0. Odds ratio was calculated to find association between preeclampsia and deranged ALT and AST. Results: The mean age of the patients was 33.30 (±4.45) years in cases and 32.96 (±4.72) in the control group. Mean gestational age was 33.88 (±4.07) weeks while 33.6 (±4.29) weeks in the control group. It was observed that body mass index was 28.90 (±2.32) in cases and 31.45 (±3.76). Parity was also almost similar in the both groups. It was observed that among cases 14 (28%) of the participants had deranged. ALT and AST value while 3 (6%) in the control group which was significant with Odds ratio >1. Conclusions: Significantly deranged liver enzymes were observed in the eclampsia patients. There is a need to conduct further study to know its relationship with disease.
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Laboratory tests of liver function are among most commonly ordered investigations. Interpretation of liver function tests requires analysis of metabolic and synthetic functions of the liver, with some parameters reflecting hepatoc...
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Laboratory tests of liver function are among most commonly ordered investigations. Interpretation of liver function tests requires analysis of metabolic and synthetic functions of the liver, with some parameters reflecting hepatocellular injury rather than measuring liver function per se. Laboratory liver function tests assist clinical assessment in identification of aetiology of liver failure, serial monitoring of disease progress, classifying severity and scoring systems, predicting deterioration and guidance to selection of candidates for liver resection, extracorporeal support devices and liver transplantation. An understanding of liver function tests is thus considered a basic scientific knowledge in providing clinical care in anaesthesia and critical care medicine.
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The goal of the present study was to investigate the relation between the extent of liver and kidney damage in pregnancy toxemic does and the responsiveness of these does to therapeutic treatment. A total of 35 late pregnant does ...
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The goal of the present study was to investigate the relation between the extent of liver and kidney damage in pregnancy toxemic does and the responsiveness of these does to therapeutic treatment. A total of 35 late pregnant does were included in thisstudy from which, ten does were proved healthy and used as a control group. Blood samples were collected for separation of serum from all animals before and after therapeutic treatment. The following serum biochemical parameters were determined in the collected samples; enzyme activities of aspartate amino tansferase (AST), alanine amino tansferase (ALT), alkaline phosphatase (ALP). Blood urea nitrogen, creatinine, glucose, total lipid, triglycerides and total cholesterol levels were also measured. Theresults of the study have showed a direct relation between the extent of liver and kidney affection and the response of the pregnancy toxemic does to conventional therapeutic treatment.
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BackgroundBiochemical substances relating to renal and hepatic function are influenced not only by individual factors such as gender, lifestyle, and age but also by ecological factors, such as altitude, climate, and ethnic backgro...
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BackgroundBiochemical substances relating to renal and hepatic function are influenced not only by individual factors such as gender, lifestyle, and age but also by ecological factors, such as altitude, climate, and ethnic background. The purpose of the present study was to establish reference intervals for 16 biochemical substances relating to renal and hepatic function in healthy Chinese adults.
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Liver disease develops in one-third of patients with cystic fibrosis (CF). It is rare for liver disease to have its onset after 20 years of age. Lung disease, however, is usually more severe in adulthood. A retrospective analysis ...
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Liver disease develops in one-third of patients with cystic fibrosis (CF). It is rare for liver disease to have its onset after 20 years of age. Lung disease, however, is usually more severe in adulthood. A retrospective analysis was performed on nine patients. Three patients required lung transplantation approximately a decade after liver transplant, and another underwent combined liver and lung transplants. Four additional patients with liver transplants are awaiting assessment for lung transplants. One patient is awaiting combined liver and lung transplants. With increased survival in CF, several patients may require more than single organ transplantation.
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Abstract Liver function test is one of the most commonly performed laboratory investigations and consists of a panel of laboratory measured serum parameters. It does not evaluate function of the liver directly but interpretation, ...
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Abstract Liver function test is one of the most commonly performed laboratory investigations and consists of a panel of laboratory measured serum parameters. It does not evaluate function of the liver directly but interpretation, as a panel, reflects underlying hepatocellular injury, metabolic and synthetic functions of the liver and supplement clinical assessment. It assists diagnosing liver failure, serial monitoring of disease progress, classifying severity and scoring systems, and selection of candidates and extent for liver resection, extracorporeal support devices and liver transplantation. An understanding of laboratory liver function tests is considered a basic scientific knowledge in clinical anaesthesia and critical care.
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The liver is the body's largest single discrete organ. It has four major functions: metabolism and synthesis; excretion; storage; and the detoxification of potential poisons. These diverse functions mean that a single test does no...
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The liver is the body's largest single discrete organ. It has four major functions: metabolism and synthesis; excretion; storage; and the detoxification of potential poisons. These diverse functions mean that a single test does not give enough information to assess fully how the liver is functioning; at least five different liver function tests are required. This article, part 2 in a four-part series, discusses the information on acute and chronic liver disease that these tests can provide, and how disease affects liver function.
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