摘要 : Erroneous expression of genetic information is a characteristic of a transformed phenotype in cancer biogenesis [ 1]. The degree of chromosomal instability in a cell can determine its fate toward proliferation or cell death. Chrom... 展开 Erroneous expression of genetic information is a characteristic of a transformed phenotype in cancer biogenesis [ 1]. The degree of chromosomal instability in a cell can determine its fate toward proliferation or cell death. Chromosomal instability manifests as aneuploidy (loss or gain of chromosomes) or as a rearrangement of chromosomal structure. For example, in human Burkitt's lymphoma, the C-MYC on-cogene is translocated downstream of the enhancer of the immunoglobulin heavy chain gene, resulting in overexpression of C-MYC, which increases both the rate of cell division and chromosomal instability , The translocation resulting in the production of the chimeric BCR-ABL fusion protein has been demonstrated to transform hematopoietic cells, resulting in chronic myelogenous leukemia in humans . Thus, chromosomal aberrations can result in overexpression of oncogenes or suppression of tumor suppressor genes, which in turn promote oncogenic transformation. 收起