摘要 : OBJECTIVE: To investigate changes of olfactory bulb (OB) volume over time in relation to olfactory function. DESIGN: Prospective, before-after trial. SETTING: Outpatient clinic of a university clinic for otorhinolaryngology. PATIE... 展开 OBJECTIVE: To investigate changes of olfactory bulb (OB) volume over time in relation to olfactory function. DESIGN: Prospective, before-after trial. SETTING: Outpatient clinic of a university clinic for otorhinolaryngology. PATIENTS: A total of 20 patients with olfactory loss participated in the study. The duration of olfactory deficits ranged from 3 months to 6 years. MAIN OUTCOME MEASURES: Olfactory function was assessed for phenyl ethyl alcohol odor threshold, odor discrimination, and odor identification. Olfactory bulb volume was determined using magnetic resonance imaging. RESULTS: In initially hyposmic patients (n = 13), changes in OB volume were found to correlate with odor threshold changes (r 0.82; P identification. CONCLUSION: As demonstrated in a longitudinal study for the first time to our knowledge, the human OB is a highly plastic structure that responds to individual changes in olfactory status. 收起