摘要 : Background: Various studies show an inverse relation between Alzheimer disease and cancer, but findings are likely to be biased by surveillance and survival bias. Plasma amyloid-beta (A beta) is defined as a preclinical feature of... 展开 Background: Various studies show an inverse relation between Alzheimer disease and cancer, but findings are likely to be biased by surveillance and survival bias. Plasma amyloid-beta (A beta) is defined as a preclinical feature of Alzheimer disease, with lower levels of A beta 42 being associated with a higher risk of Alzheimer disease. To get more insight into the biological link between Alzheimer disease and cancer, we investigated plasma Ab levels in relation to the risk of cancer. Methods: Between 2002 and 2005, we measured plasma A beta 40 and A beta 42 levels in 3,949 participants from the population-based Rotterdam Study. These participants were followed until the onset of cancer, all-cause dementia, death, loss to follow-up, or January 1, 2014, whichever came first. We used Cox proportional hazards models to investigate the association between plasma A beta 40 and A beta 42 levels, and the risk of cancer. Analyses were stratified by cancer site. Results: During a median (interquartile range) follow-up of 9.0 years (6.9-10.1), 560 participants were diagnosed with cancer. Higher levels of log(2) plasma A beta 40 and A beta 42 were associated with a higher risk of cancer [hazard ratio per standard deviation increase for A beta 40 = 1.12 (95% confidence interval, CI = 1.02-1.23) and A beta 42 = 1.12 (95% CI = 1.03-1.23)]. These effect estimates were most pronounced for hematologic cancers, urinary tract cancers, and cancers of unknown primary origin. Conclusions: We found that higher levels of both plasma A beta 40 and A beta 42 were associated with a higher risk of cancer. Impact: Our study suggests a potential biological link between Alzheimer disease and cancer. The pathophysiologic role of Ab in cancer and its causality warrant further investigation. 收起