摘要
:
Bicyclo[2.2.2]octane derivatives possessing a quaternary bridgehead carbon were synthesized with excellent diastereoselectivity in nearly optically pure form by diphenylprolinol silyl ether mediated domino Michael/Michael reaction...
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Bicyclo[2.2.2]octane derivatives possessing a quaternary bridgehead carbon were synthesized with excellent diastereoselectivity in nearly optically pure form by diphenylprolinol silyl ether mediated domino Michael/Michael reaction of alpha,beta-unsaturated aldehyde and cyclohex-2-en-1-one bearing an electron-withdrawing group at the 3-position. Carbonitrile, alkoxycarbonyl, and sulfonyl substituents were successfully employed as a suitable electron-withdrawing group at the 3-position of cyclohex-2-en-1-one.
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