摘要 : AbstractBACKGROUND:Depression is a widespread, global problem, increasingly linked with vitamin D deficiency in the literature. However, a knowledge gap persists regarding the relationship between depressive symptoms and vitamin D... 展开 AbstractBACKGROUND:Depression is a widespread, global problem, increasingly linked with vitamin D deficiency in the literature. However, a knowledge gap persists regarding the relationship between depressive symptoms and vitamin D intake.OBJECTIVE:To determine the association between vitamin D supplementation and depressive symptoms in adults (aged 18+ years).METHODS:This study consists of a systematic review and meta-analysis of randomized controlled trials (RCTs), published before January 2019. Pooled summary estimates and between-study heterogeneity were examined.RESULTS:Ten RCTs (total participants?=?3336; median duration?=?12 months) were included. An association was found between high vitamin D supplementation (≥4000 IU) and reduced depressive symptoms, but not in the case of lower levels of vitamin D supplementation (<4000 IU). Neither baseline serum vitamin D before supplementation, nor the depression-scoring scales used affected this association. The overall quality of evidence was graded as ‘moderate’.CONCLUSIONS:Vitamin D supplementation at greater than 4000 IU was observed to have a positive effect on depressive symptoms. Future efforts could focus on obtaining higher-quality evidence with standardized RCT methodologies to confirm this association. 收起