摘要 : The reaction of 2-amino-4-(4-fluorophenyl)-4H-benzo[h]chromene-3-carbonitrile (3) with NN-dimethyldichlo-romethyleniminium chloride gave the tetracyclic chloro compound 4 which reacted readily with nucleophilic agents Such as morp... 展开 The reaction of 2-amino-4-(4-fluorophenyl)-4H-benzo[h]chromene-3-carbonitrile (3) with NN-dimethyldichlo-romethyleniminium chloride gave the tetracyclic chloro compound 4 which reacted readily with nucleophilic agents Such as morpholine, piperidine, methylpiperazine to afford 5a-c. Furthermore, displacement of the halogen atom Of Compound 4 by hydrazine yielded 5d. Compound 5d served as the precursor to pyranopyrimidine derivatives 6-11 by the reactions with triethyl orthoformate, NN-dimethyldichloromethyleniminium chloride, carbon disulfide, ethyl acetoacetate, ethyl cyanoacetate and sodium nitrite in acetic acid. 收起