摘要 : Kinetic resolution of D, L-myo-inositol derivatives having a 1, 2-diol functionality by monobenzoylation was achieved using (R,R)-Ph-BOX-Cu(II) as a catalyst. The monobenzoylation preferentially took place at the 1, 2-diol functio... 展开 Kinetic resolution of D, L-myo-inositol derivatives having a 1, 2-diol functionality by monobenzoylation was achieved using (R,R)-Ph-BOX-Cu(II) as a catalyst. The monobenzoylation preferentially took place at the 1, 2-diol functionality via a highly enantiodiscriminatory process, which was largely influenced by a substituent at the position adjacent to the 1,2-diol functionality. This method was applied to a synthesis of biologically important D-inositol-1-phosphate. (C) 2004 Elsevier Ltd. All rights reserved. 收起