摘要 : The near-infrared spectroscopic (NIRS) method and multiple linear regression (MLR) method have been used for determination of the moisture content in tetracycline hydrochloride and oleandomycine phosphate in powdered forms.Chemome... 展开 The near-infrared spectroscopic (NIRS) method and multiple linear regression (MLR) method have been used for determination of the moisture content in tetracycline hydrochloride and oleandomycine phosphate in powdered forms.Chemometric calibration model has been developed using two absorption bands: at 5170 and 6850 cm-1.The determined mean moisture content in veterinary drugs Vetacyclinum pulvis (VP) and Polzomycine (P) varied in the range 2.52-3.54%.Detection limit and quantification limit were 0.31% and 0.92% for VP,and 0.58% and 1.75% for P,respectively.Intra-day and intermediate precisions of the proposed determination by the NIR method have been evaluated and RSD values of 0.99% and 1.89% for VP,and 0.85% and 1.13% for P were obtained.These numbers indicate reasonable repeatability and intermediate precision of NIR method.The accuracy of this method was compared to that of the reference Karl Fischer's method,and they were found consistent (99.2-100.1% and 99.1-99.8%,respectively),which proves applicability of the proposed NIR method in the routine determination of the moisture content in veterinary drugs. 收起