摘要 : A Cell article reports that lymph node metastases can suppress the immune system, thereby promoting further cancer spread in mouse models; this is corroborated in patients as described in a letter in this issue of Cancer Cell. The... 展开 A Cell article reports that lymph node metastases can suppress the immune system, thereby promoting further cancer spread in mouse models; this is corroborated in patients as described in a letter in this issue of Cancer Cell. The lymph node thus actively generates a cancer-permissive environment and is an untapped target to manipulate the immune system. ‘‘One bad apple can spoil the bunch’’ is a common proverb that warns of the active influence of rotting fruit. Perishing produce passively warns us of the impending decay of other produce harvested at a similar time. But rotting produce releases ethylene, a development hormone, through skin breaks and forces neighboring fruit to quickly mature. In an article recently published in Cell, Reticker-Flynn et al. (2022) demonstrate that a tumor-infiltrated lymph node, like a bad apple, can prime the environment toward undesirable consequences. 收起