摘要 : Double-stranded DNA breaks (DSBs) can be generated by endogeneous endonu-cleases, ionizing radiation, and chemical compounds such as topoisomerase inhibitors as well as apoptosis inducers. A DSB is repaired through one of three ma... 展开 Double-stranded DNA breaks (DSBs) can be generated by endogeneous endonu-cleases, ionizing radiation, and chemical compounds such as topoisomerase inhibitors as well as apoptosis inducers. A DSB is repaired through one of three major recombination pathways (Fig. 1). 收起