摘要 : For the last two decades, Bioceramics Group of CSIR-Central Glass and Ceramic Research Institute (CSIR-CGCRI), Kolkata has been engaged in the development of new generation of ceramic materials for different biomedical application... 展开 For the last two decades, Bioceramics Group of CSIR-Central Glass and Ceramic Research Institute (CSIR-CGCRI), Kolkata has been engaged in the development of new generation of ceramic materials for different biomedical applications. The group has developed hip joint prosthesis with ceramic heads, hydroxyapatite-based bone fillers and ocular implants which after successful animal trials have been assessed through clinical trials at different hospitals (Calcutta Medical Research Institute, Kolkata; Advanced Medical Research Institute, Kolkata; All India Institute of Medical Sciences, New Delhi and Moulana Azad Medical College, New Delhi for hip implants and bone fillers and Eye Care and Research Centre, Kolkata; All India Institute of Medical Sciences, New Delhi, Sir Gangaram Hospital, New Delhi, Moulana Azad Medical College, New Delhi, Shankara Nethralaya, Chennai, Sri Sankardeva Nethralaya, Guwahati, Sarojini Devi Eye Hospital, Hyderabad and Disha Eye Hospital, Barackpore) in the country. These technologies have been commercialized and available in Indian market through M/s IFGL Bioceramics Ltd., Kolkata since January, 2005. Thereafter, few of the technologies have been transferred to other Indian companies who are in the process of obtaining manufacturing license from DCGI before commercialization. The Institute has also developed coatings on metallic implants by plasma spraying hydroxyapatite/other calcium phosphates for cementless fixation in the human subjects. These clinical trailswere primarily carried out at Sancheti Institute of Orthopedic and Rehabilitation, Pune under the leaderships of Padmavibhushan Dr. K.H. Sancheti. Further, the Institute has also actively participated in few CSIR network programmes to develop coated implants using diamond-like nano-composite (DLN) and standardize laser engineered net shaping (LENS) process for development of patient specific prosthesis of irregular shapes.In addition, the Institute has developed adequate expertise to develop different types of glass and glass-ceramic coatings on various metals and alloys including stainless steels, titanium and its alloys, nimonic and other super alloys for various engineering applications. Hydroxyapatite dispersed bioactive glass compositions for application as a coating on titanium and stainless steel implants have been developed and commercialized by M/s IFGL Bioceramics Limited, Kolkata. Coatings of glass-ceramics developed by this enameling technique showed desirable phases of calcium phosphates retained within a highly bioactive glass matrix which in turn improved the performance of the coating and made the coating process simpler. The Institute has already developed adequate infrastructure and network with the doctors to develop different types of devices. In the following sections, glimpse of few matured technologies emanated from the Bioceramics group of CSIR-CGCRI are being elaborated. In this article, we aim to provide overview of medical materials and implant technologies developed at CSIR-CGCRI, which have been successfully completed clinical trials and commercialized. 收起