摘要 : Selective superoxide dismutase (SOD) mimetics are potentially useful in pathological conditions in which there is an overproduction of the superoxide anion O<inf>2</inf>.^-. These pathological conditions include inflamma... 展开 Selective superoxide dismutase (SOD) mimetics are potentially useful in pathological conditions in which there is an overproduction of the superoxide anion O<inf>2</inf>.^-. These pathological conditions include inflammation, ischemia/reperfusion, shock, various cardiovascular disorders, amyotrophic lateral sclerosis (ALS) and other neurode-generative disorders. A major step forward in this field was the development of small-molecule selective SOD mimetics that penetrate cell membranes. These selective SOD mimetics catalytically remove O<inf>2</inf>.^- without interfering with nitric oxide (NO), peroxynitrite (ONOO-) or other radicals such as hydroxyl radical or hydrogen peroxide (H<inf>2</inf>O<inf>2</inf>). These selective SOD mimetics (SC-52608, SC-55858, M-40403 and M-40401) have been shown to have benefits in animal models of inflammation, ischemia/reperfusion, shock, thrombosis and diabetes. The next challenge with selective SOD mimetics is to develop therapeutic potential into therapeutic agents. 收起