摘要 : The organocatalytic asymmetric Michael addition of 2,2-dimethyl-1,3-dioxiin-5-one (1) was performed with various nitro alkenes 2 using a number of proline-based catalysts (AM) affording polyfunctional nitro ketones 3. Reverse dias... 展开 The organocatalytic asymmetric Michael addition of 2,2-dimethyl-1,3-dioxiin-5-one (1) was performed with various nitro alkenes 2 using a number of proline-based catalysts (AM) affording polyfunctional nitro ketones 3. Reverse diastereoselectivity was observed with the diphenylprolinol catalyst J, and the best diastereo- and enantiomeric excesses were achieved with the sulfonamide catalyst M (de = 84-98%, ee = 81-86%). ((c) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006). 收起