摘要 : Chiral Bronsted acid, D-camphorsulfonic acid, was found to be practical and efficient in the catalysis of the enantioselective Michael-type Friedel-Crafts reactions of indoles with aromatic enones to afford the corresponding beta-... 展开 Chiral Bronsted acid, D-camphorsulfonic acid, was found to be practical and efficient in the catalysis of the enantioselective Michael-type Friedel-Crafts reactions of indoles with aromatic enones to afford the corresponding beta-indolyl ketones in excellent yields and moderate enantioselectivities. A surprising synergistic effect was discovered between BmimBr and D-CSA which leads to active catalytic systems for the Friedel-Crafts reaction. The efficiency of these systems might result from the catalytic Lewis acid activation of the Bronsted acids. 收起