摘要: Obstructive sleep apnea syndrome(OSAS)is a disorder characterized by snoring,recurring bouts of cessation of breathing during sleep,and daytime somnolence.OSAS may have a direct deleterious influence on cardiovascular outcomes.Cor... 展开 Obstructive sleep apnea syndrome(OSAS)is a disorder characterized by snoring,recurring bouts of cessation of breathing during sleep,and daytime somnolence.OSAS may have a direct deleterious influence on cardiovascular outcomes.Coronary artery disease is one of the cardiovascular diseases influenced by OSAS(CAD).The prevalence of OSAS rose with the degree of coronary artery disease. Objectives: This study aims to summarize the evidence concerning the effect of obstructive sleep apnea syndrome on coronary artery disease in meta analysis. Methods: All these studies for this dissertation were carried out using several databases,such as PubMed,ScienceDirect,Cochrane Library,and Google Scholar.All searching protocol in this dissertation was carried out using the Preferred Reporting Items for Systematic Review and Meta-Analysis(PRISMA)2020 guidelines.Categorical variables were analyzed as proportions.Higgins I2 was used to calculate the statistical heterogeneity.Bias in publication was assessed using a funnel plot.Data analysis used Review Manager(RevMan)5.4.1.The p value＜0.05 was considered statistically significant. Result: This review includes a total of 20 studies.All studies were observational studies with the longest follow-up duration of 8 years.Most of the studies reported that CAD patients with OSAS have poorer clinical outcomes than CAD patients without OSAS.Based on meta analysis,CAD patients with OSAS had a significantly 1.55 times higher risk of experiencing MACE than CAD patients without OSAS(RR 1.55;95％Cl 1.20-2.01;p=0.0008);an unsignificantly 4.62 times higher risk for all-cause mortality than CAD patients without OSAS(RR 4.62;95％Cl 0.78-27.26;p=0.09);unsignificantly 1.12 times higher risk for CAC presence than CAD patients without OSAS(RR 1.12;95％Cl 0.63-2.00;p=0.70);and a significantly mean difference for AHI score than CAD patients without OSAS(MD 26.70;95％Cl 23.05-30.36;p＜0.001).Furthermore,based on the results of subgroup analysis,the risk of MACE was greater in the study group with mean AHI score＜30,which was 1.68 times compared to 1.65 times in the study group with mean AHI score＞30.However,there was no significant difference between the two groups(Chi square;p=0.94). Conclusion: CAD patients with OSAS have poorer clinical outcomes than CAD patients without OSAS.Moreover,CAD patients with OSAS had a higher risk of experiencing MACE,all-cause mortality,presence of coronary artery calcification(CAC),and Apnea-Hypopnea Index(AHI)score than CAD patients without OSAS. 收起