摘要: We have examined a number of coal-derived liquids for their carcinogenic activity in attempts to compare the relative potencies of liquids derived from various processes and identified the components responsible for the carcinogen... 展开 We have examined a number of coal-derived liquids for their carcinogenic activity in attempts to compare the relative potencies of liquids derived from various processes and identified the components responsible for the carcinogenic activity. Fractionation appeared to increase the activity. Activities of the materials tested did not necessarily reflect the levels of known carcinogens such as benzo(a)pyrene (BaP), nor were they simple summations of the biological activities of individual components. These observations suggest that there are interactions among components of these complex mixtures which influence the response of the animal to the carcinogenic constituents. Data obtained in our laboratory indicate that known mutagens and carcinogens contained in complex mixtures derived from coal may show either suppressed or enhanced activity depending upon the composition of the mixture. (ERA citation 11:025328) 收起