摘要 : Pregnant women are physiologically prone to glucose intolerance, while the puerperium represents a critical phase for recovery. However, how air pollution disrupts glucose homeostasis during the gestational and early postpartum pe... 展开 Pregnant women are physiologically prone to glucose intolerance, while the puerperium represents a critical phase for recovery. However, how air pollution disrupts glucose homeostasis during the gestational and early postpartum periods remains unclear. This prospective cohort study conducted an oral glucose tolerance test and measured the insulin levels of 834 pregnant women in Guangzhou, with a follow-up for 443 puerperae at 6-8 weeks postpartum. Residential PM_(2.5) and five chemical components were estimated by an established spatio-temporal model. The adjusted linear model showed that an IQR increase in gestational PM_(2.5) exposure was associated with an increase of 0.17 mmol/L (95% CI: 0.06, 0.28) in fasting plasma glucose (FPG) and 0.24 (95% CI: 0.05, 0.42) in the insulin resistance index. Postpartum PM_(2.5) exposure was linked to a 0.17 mmol/L (95% CI: 0.05, 0.28) elevation in FPG per IQR, with a strengthened association found in women with gestational diabetes (P_(interaction) = 0.003). In the quantile-based g-computation model, NO_3~- consistently contributed to the combined effect of PM_(2.5) components on gestational and postpartum FPG. This study was the first to suggest that PM_(2.5) components were associated with exacerbated gestational insulin resistance and elevated postpartum FPG. Targeted interventions reducing the emissions of toxic PM_(2.5) components are essential to improving maternal glucose metabolism. 收起