摘要 : Here we report the examination of twoconvenient strategies, the use of a D-amino acid residue or aglycoside segment, for increasing the proteolytic resistance ofsupramolecular hydrogelators based on small peptides. Ourresults show... 展开 Here we report the examination of twoconvenient strategies, the use of a D-amino acid residue or aglycoside segment, for increasing the proteolytic resistance ofsupramolecular hydrogelators based on small peptides. Ourresults show that the introduction of D-amino acid or glycosideto the peptides significantly increases the resistance of thehydrogelators against proteinase K, a powerful endopeptidase.The insertion of D-amino acid in the peptide backbone,however, results relatively low storage moduli of the hydrogels,likely due to the disruption of the superstructures of themolecular assembly. In contrast, the introduction of aglycoside to the C-terminal of peptide enhances thebiostability of the hydrogelators without the significant decrease of the storage moduli of the hydrogels. This work suggeststhat the inclusion of a simple glycogen in hydrogelators is a useful approach to increase their biostability, and the gainedunderstanding from the work may ultimately lead to development of hydrogels of functional peptides for biomedical applicationsthat require long-term biostability. 收起