摘要 : Activated on the surface of nanometre-sized TiO_2, NO gas can easily react with aliphatic cyclic amines and aryl free radicals at RT under atmospheric pressure to offer NONOates and cupferron sodiums, respectively.An increasing kn... 展开 Activated on the surface of nanometre-sized TiO_2, NO gas can easily react with aliphatic cyclic amines and aryl free radicals at RT under atmospheric pressure to offer NONOates and cupferron sodiums, respectively.An increasing knowledge of the role of nitric oxide (NO) in a number of physiological and pathological processes has stimulated efforts to target the NO pathway pharmacologically. Since NO is a pleiotropic molecule, the selective delivery of NO to the specific tissues has recently been attracting much attention, particularly in the field of anticancer therapy. Among the various NO donors that directly or indirectly release NO being used in biomedical research, nitrogen-bound diazen-1-ium-1,2-diolate (formally known as NONOate) is the most important, owing to its ability to deliver NO to some specific tissues. 收起