摘要 : The objective of this study was to investigate the reproductive success (fertility and fecundity) of medaka (Oryzias latipes) exposed to 4-nonylphenol (4-NP) in water and the viability of their F, offspring. In addition, we measur... 展开 The objective of this study was to investigate the reproductive success (fertility and fecundity) of medaka (Oryzias latipes) exposed to 4-nonylphenol (4-NP) in water and the viability of their F, offspring. In addition, we measured the bioconcentration of 4-NP in eggs. After a 21-d exposure to 100 mu g/l 4-NP, medaka showed reduced egg production and fertility. Hepatic vitellogenin levels were increased significantly in mates treated with 10, 50 and 100 mu g/l of 4-NP. In the F, generations, the hatchability and time to hatching of embryos in the 100 mu g/l treatment group were adversely affected, and 2-7 mu g 4-NP/g egg was found in spawned eggs (the bioconcentration factor: 30-100). These results indicate that (1) 4-NP adversely affected the reproduction (fecundity and fertility) of adult medaka, (2) 4-NP accumulated in eggs through maternal transfer and (3) these levels of 4-NP were associated with adverse effects in the F, offspring. (c) 2006 Elsevier Ltd. All rights reserved. 收起