摘要 : Gasdermin D(GSDMD)is the pore-forming executor of pyroptosis and cytokine secretion during inflammasome activation.In a recent study in Nature,Du et al.report that S-palmitoylation of human GSDMD at Cys191(mouse Cys192)is a key re... 展开 Gasdermin D(GSDMD)is the pore-forming executor of pyroptosis and cytokine secretion during inflammasome activation.In a recent study in Nature,Du et al.report that S-palmitoylation of human GSDMD at Cys191(mouse Cys192)is a key regulatory step that controls both its activation and interactionwith membranes.Palmitoylation is a reversible post-translational modification(PTM)of proteins involving the addition of a 16-carbon fatty acid,palmitic acid,by cellular palmitoyltransferases(PATs).Palmitoylation commonly occurs on cysteine residues(S-palmitoylation),and less frequently on serine and threonine residues(O-palmitoylation).Palmitoylation most commonly affects membrane localization of proteins,although it can also affect protein stability.Gasdermins(GSDMs)are a family of pore-forming proteins that control the induction of lytic cell death known as pyroptosis. 收起