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Identification of SARS-CoV-2-against aptamer with high neutralization activity by blocking the RBD domain of spike protein 1

[期刊]

《信号转导与靶向治疗（英文）》 2021年7期

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摘要 : Dear Editor,The ongoing outbreak of coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)poses a great threat to the public health of people and the normal economic and social deve... 展开

作者	Ge Yang Ziyue Li Irfan Mohammed Liping Zhao Wei Wei Haihua Xiao Weisheng Guo Yongxiang Zhao Feng Qu Yuanyu Huang
作者单位	School of Life Science Advanced Research Institute of Multidisciplinary Science Institute of Engineering Medicine Key Laboratory of Molecular Medicine and Biotherapy Beijing Institute of Technology Beijing China + - 所属机构：北京理工大学 State Key Laboratory of Biochemical Engineering Institute of Process Engineering Chinese Academy of Sciences Beijing China Beijing National Laboratory for Molecular Sciences State Key Laboratory of Polymer Physics and Chemistry Institute of Chemistry Chinese Academy of Sciences Beijing China Translational Medicine Center Key Laboratory of Molecular Target&Clinical Pharmacology and the State Key Laboratory of Respiratory Disease School of Pharmaceutical Sciences&the Second Affiliated Hospital Guangzhou Medical University Guangzhou China + - 所属机构：广州医科大学 National Center for International Research of Biological Targeting Diagnosis and Therapy Guangxi Key Laboratory of Biological Targeting Diagnosis and Therapy Research Guangxi Medical University Nanning Guangxi China + - 所属机构：广西医科大学
期刊名称	《信号转导与靶向治疗（英文）》
期刊英文名称	《信号转导与靶向治疗（英文）》
页码/总页数	P.1985-1988 / 4
语种/中图分类号	汉语 / R373
关键词	death acute respiratory
DOI	10.1038/s41392-021-00649-6
基金项目	This work was supported by the National Natural Science Foundation of China(21675012,21874010,21827810,31871003,and 31901053);the Beijing Nova Program from Beijing Municipal Science&Technology Commission(Z201100006820005);the Beijing-Tianjin-Hebei Basic Research Cooperation Project(19JCZDJC64100);the Young Elite Scientist Sponsorship Program of Beijing Association for Science and Technology(2020-2022);the Fundamental Research Funds for the Central Universities from Beijing Institute of Technology(2018CX01023);the Hunan Provincial Natural Science Foundation of China(2018JJ1019);the Hu-Xiang Young Talent Program(2018RS3094);the Natural Science Foundation of Guangdong Province(2019A1515010776);the Postdoctoral Science Foundation of China(2020M670169);Guangxi Key Research and Development Project(No.AB20117001)。