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Background: The spectrum of heart diseases varies between and within countries, depending on the stage of epidemiological transition and risk factor profiles, understanding this spectrum requires regional and national data for eac...
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Background: The spectrum of heart diseases varies between and within countries, depending on the stage of epidemiological transition and risk factor profiles, understanding this spectrum requires regional and national data for each region and country. Objective: To assess the spectrum of heart diseases in Sanaa, the Capital of Yemen republic. Methods: This retrospective, descriptive registry reviewed abnormal echocardiographic findings of 6044 patients aged 0 - 100 years, (3264 male patients (54%), and 2780 female patients (46%) from January 2019 to May 2022. Results: Hypertensive heart disease (HHD) (n: 1597, 26.42%), valvular heart disease (VHD) (n: 1356, 22.44%), heart failure with reduced ejection fraction (HFrEF) (n: 1189, 19.67%) and Ischemic heart disease (I.H.D) (n: 1027, 16.99%) were the most frequent comorbidities. Congenital heart diseases (CHDs) were detected in 123 (2%) of the patients, with the most common ones including atrial septal defect (ASD) (n: 38, (30.89%)) and ventricular septal defect (VSD) (n: 28, (22.76%)). Rheumatic heart disease (RHD) was observed in 693 (51.10%) patients, senile valvular degenerative lesions (SVDL) in 366 (26.99%), mitral valve prolapse (MVP) were detected in 297 (21.9%). Mitral insufficiency (n: 965, (71.2%)) was detected as the most frequent VHD, followed by aortic insufficiency (n: 259, (19.1%)), and tricuspid insufficiency (n: 62, (4.6%)), mitral valve stenosis (n: 46, (3.4%)) and aortic stenosis (n: 24, (1.8%)) was the least common VHD. Conclusion: In the present study, we found that HHD was the most common comorbidity, followed by VHD, HFrEF and IHD. Moreover, the most common VHD was mitral insufficiency and the most common CHD was ASD.
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To investigate the frequencies and patterns of cardiovascular diseases (CVDs), including rheumatic and congenital heart diseases, among patients with abnormal hearts assessed by echocardiographic examination. This retrospective, d...
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To investigate the frequencies and patterns of cardiovascular diseases (CVDs), including rheumatic and congenital heart diseases, among patients with abnormal hearts assessed by echocardiographic examination. This retrospective, descriptive registry reviewed abnormal echocardiographic findings of 1140 patients aged 0–100?years who were admitted to the cardiology outpatient clinic at a tertiary training institution in Mogadishu. Hypertensive heart disease (HHD) (n:454, 39.8%), valvular heart disease (VHD) (n:395, 34.6%), and heart failure with reduced ejection fraction (HFrEF) (n:351, 30.8%) were the most frequent comorbidities. Congenital heart diseases (CHDs) were detected in 151 (13.2%) of the patients, with the most common ones including atrial septal defect (ASD) (n:37, 3.2%) and ventricular septal defect (VSD) (n:26, 2.3%). Rheumatic heart disease (RHD) was observed in 84 (7.4%) patients, among whom the most common age range was 16–30?years (40.5%), followed by 31–45?years (31%) and 0–15?years (15.5%). Mitral insufficiency (n:541, 47.5%) was detected as the most frequent VHD, followed by aortic insufficiency (n:437, 38.3%), and tricuspid insufficiency (n:264, 23.2%) and mitral valve stenosis (n:39, 3.4%) was the least common VHD. In the present study, we found that HHD was the most common comorbidity, followed by VHD, and HFrEF. Moreover, the most common VHD was mitral insufficiency and the most common CHD was ASD.
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Organ growth occurs through the integration of external growth signals during the G1 phase of the cell cycle to initiate DNA replication. Although numerous growth factor signals have been shown to be required for the proliferation...
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Organ growth occurs through the integration of external growth signals during the G1 phase of the cell cycle to initiate DNA replication. Although numerous growth factor signals have been shown to be required for the proliferation of cardiomyocytes, genetic studies have only identified a very limited number of transcription factors that act to regulate the entry of cardiomyocytes into S phase. Here, we report that the cardiac para-zinc-finger protein CASZ1 is expressed in murine cardiomyocytes. Genetic fate mapping with an inducible Casz1 allele demonstrates that CASZ1-expressing cells give rise to cardiomyocytes in the first and second heart fields. We show through the generation of a cardiac conditional null mutation that Casz1 is essential for the proliferation of cardiomyocytes in both heart fields and that loss of Casz1 leads to a decrease in cardiomyocyte cell number. We further report that the loss of Casz1 leads to a prolonged or arrested S phase, a decrease in DNA synthesis, an increase in phospho-RB and a concomitant decrease in the cardiac mitotic index. Taken together, these studies establish a role for CASZ1 in mammalian cardiomyocyte cell cycle progression in both the first and second heart fields.
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Abstract Introduction Partial heart transplants are a new type of pediatric transplant that replace defective heart valves with the parts of matched donor hearts containing the necessary valves. Short‐term outcomes of partial hea...
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Abstract Introduction Partial heart transplants are a new type of pediatric transplant that replace defective heart valves with the parts of matched donor hearts containing the necessary valves. Short‐term outcomes of partial heart transplants are excellent, but long‐term outcomes are unknown. In order to predict the long‐term outcomes of partial heart transplants, we evaluated long‐term growth and function of semilunar heart valves transplanted in infancy as part of a heart transplant. Methods All children who underwent infant heart transplantation at a single center from 1997 to 2014 were included in this study. Children in whom echocardiograms after heart transplantation and after 10?years were not available for review were excluded. The echocardiograms were reviewed by two authors to analyze semilunar valve annulus diameters, Z‐scores, peak valve gradients, and valve regurgitation. Statistical difference was determined using two‐tailed, paired sample t‐tests with Bonferroni correction for multiple comparisons. Results Data from 15 patients were analyzed. The aortic valve annulus averaged 1.3?cm (range 0.7–1.8?cm) immediately after transplantation and grew to an average of 1.7?cm (range 1.4–2.3?cm) after 10?years (p?收起
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An abbreviation to honor and celebrate a world day for one of these two great concepts: “World Children Heart Day” or “World Congenital Heart Disease Day” “...thanks for all of those who give their hearts to children with lov...
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An abbreviation to honor and celebrate a world day for one of these two great concepts: “World Children Heart Day” or “World Congenital Heart Disease Day” “...thanks for all of those who give their hearts to children with love ...” The presence of heart diseases in children is very difficult for parents and is accompanied by a sad feeling. Many different types of heart diseases can affect children. These diseases have a wide spectrum and include the main categories: congenital heart diseases (CHDs), acquired heart diseases, heart failure and arrhythmias. Among these, congenital heart diseases are of great importance and are an important and fundamental health problem in all countries of the world. ~ 9% of child deaths are due to congenital birth defects and congenital heart diseases are the most common type of congenital birth defects. in every 1000 live births, 8-12 infants are affected and every 4 affected children, one infant has a severe, serious and complicated type of the disease. This type is fatal in infancy and urgent need for diagnosis, intervention and surgical procedure. [1,2] CHDs have various complications and disabilities, mortality and also high costs for healthcare systems. 30% of affected children have developmental delays and cognitive disorders. These disorders in complex and severe cases are more common. Complications and long-term problems of CHDs include stenosis and insufficiency of heart valves, pulmonary hypertension, Arrythmia, Endocarditis, Heart failure, Redo cardiac surgery or Intervention, brain complications and stroke and mental disorders. [2] Currently with better access to healthcare services and advances in the field of pediatric cardiology and pediatric cardiac surgery, 95% of uncomplicated cases and 70% of complex and severe cases, reach the age of 18 and above. [2] most cases of death occur in countries with low socioeconomic level. Currently about 12 million people in the world live with congenital heart diseases [3]. In order to make society and the general public aware of the importance of heart diseases in children, especially congenital heart diseases, there is a need to set a world day for this issue. With the various educational programs of the governments and the healthcare system of the countries on this day, we can hope that better planning for the management of heart diseases in children will be done at different levels of the society and ultimately the mortality rate and complications of these diseases will be reduced. Undoubtedly, having healthier children brings a better and more beautiful future for us and the generations after us. For this purpose, an abbreviation can be used: “WCHD” This can mean two important issues: “World Children Heart Day” or “World Congenital Heart Disease Day”. What day can be chosen in the calendar for this purpos?.
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Primary cardiac lymphoma is an extremely rare entity which accounts for approximately 5.6% of all malignant cardiac tumours. These tumours usually present as pericardial effusions, intracardiac masses, arrhythmias or other non-spe...
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Primary cardiac lymphoma is an extremely rare entity which accounts for approximately 5.6% of all malignant cardiac tumours. These tumours usually present as pericardial effusions, intracardiac masses, arrhythmias or other non-specific manifestations. Since the clinical course is often remarkably acute in onset and short in duration, the diagnosis of cardiac lymphoma is often not made ante mortem. We describe a high-grade immunoblastic lymphoma, diagnosed at autopsy, in an elderly patient, initially presenting with a pericardial effusion and a small nodule in the right atrium. Since most primary cardiac lymphomas are lymphosarcomas and reticular cell sarcomas, an immunoblastic sarcoma as found in this case is very unusual.
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Left ventricular assist devices are becoming an increasingly prevalent therapy for patients with Stage D heart failure with reduced ejection fraction. Technological advances have improved the durability of these devices and have s...
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Left ventricular assist devices are becoming an increasingly prevalent therapy for patients with Stage D heart failure with reduced ejection fraction. Technological advances have improved the durability of these devices and have significantly lengthened survival in these patients. Quality of life is also improved, although adverse events related to device therapy remain common. Nevertheless, with the continuing organ donor shortage for cardiac transplantation, left ventricular assist devices are frequently serving as a substitute for transplant, particularly in the elderly patient. (C) 2015 by the American College of Cardiology Foundation.
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Heart transplantation remains the gold standard for long-term cardiac replacement, but a shortage of donor organs will always limit this option. For both transplant-eligible and noneligible patients, advances in mechanical circula...
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Heart transplantation remains the gold standard for long-term cardiac replacement, but a shortage of donor organs will always limit this option. For both transplant-eligible and noneligible patients, advances in mechanical circulatory support have revolutionized the options for the management of end-stage heart failure, and this technology continues to bring us closer to a true alternative to heart transplantation. This review provides a perspective on the past, present and future of mechanical circulatory support and addresses the changes in technology, patient selection and management strategies needed to have this therapy fully embraced by the heart failure community, and perhaps replace heart transplantation either as the therapy of choice or as a strategy by which to delay transplantation in younger patients.
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Background: Insufficient data delineate outcomes for Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) profile 1 patients with the total artificial heart (TAH).
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Background: Heart transplantation in the neonatal period is associated with excellent survival. However, outcomes data are scant and have been obtained primarily from two single-center reports within the United States. We sought t...
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Background: Heart transplantation in the neonatal period is associated with excellent survival. However, outcomes data are scant and have been obtained primarily from two single-center reports within the United States. We sought to analyze the outcomes of all neonatal heart transplants performed in the United States using the United Network for Organ Sharing (UNOS) dataset. Methods: The UNOS dataset was queried for patients who underwent infant heart transplantation from 1987 to 2021. Patients were divided into two groups based on age - neonates (<=31 days), and older infants (32 days-365 days). Demographic and clinical characteristics were analyzed and compared, along with follow up survival data. Results: Overall, 474 newborns have undergone heart transplantation in the United States since 1987. Freedom from death or re-transplantation for neonates was 63.5%, 58.8% and 51.6% at 5, 10, and 20 years, respectively. Patients in the newborn group had lower unadjusted survival compared to older infants (p < .001), but conditional 1-year survival was higher in neonates (p = .03). On multivariable analysis, there was no significant difference in survival between the two age groups (p = .43). Black race, congenital heart disease diagnosis, earlier surgical era, and preoperative mechanical circulatory support use were associated with lower survival among infant transplants (p < .05). Conclusions: Neonatal heart transplantation is associated with favorable long-term clinical outcomes. Neonates do not have a significant survival advantage over older infants. Widespread applicability is limited by the small number of available donors. Efforts to expand the donor pool to include non-standard donor populations ought to be considered.
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