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    [期刊]   Robinson, Philip C.   Dalbeth, Nicola   《Expert opinion on pharmacotherapy》    2017年18卷13/18期      共7页
    摘要 : Introduction: Gout is a common form of inflammatory arthritis caused by deposition of monosodium urate crystals. The central strategy for effective long-term management of gout is serum urate lowering. Current urate-lowering drugs... 展开
    关键词 : Lesinurad   urate   gout   kidney  

    摘要 : Three chemometric assisted spectrophotometric approaches were designed for precise quantitative analysis of lesinurad and allopurinol, in their recently FDA approved combination pharmaceutical dosage form. By utilizing the recorde... 展开

    摘要 : (+)- and (?)-Lesinurad were isolated as atropisomers from racemic lesinurad for the first time. No interconversion was observed between the two atropisomers under various conditions tested. The two atropisomers showed significant ... 展开
    关键词 : Atropisomer   gout   hyperuricemia   lesinurad  

    摘要 : Abstract Lesinurad is a novel selective uric acid reabsorption inhibitor approved for treatment of hyperuricemia associated with gout in combination with xanthine oxidase inhibitors (XOIs). Open‐label pharmacokinetic studies were... 展开
    关键词 : lesinurad   gout   colchicine   NSAIDs   pharmacokinetics  

    摘要 : Abstract Lesinurad is a novel selective uric acid reabsorption inhibitor approved for treatment of hyperuricemia associated with gout in combination with xanthine oxidase inhibitors (XOIs). Open‐label pharmacokinetic studies were... 展开
    关键词 : lesinurad   gout   colchicine   NSAIDs   pharmacokinetics  

    摘要 : Lesinurad is a novel selective uric acid reabsorption inhibitor which has been recently approved for the treatment of the chronic gout. Four simple mathematical spectrophotometric methods have been developed for the quantitative a... 展开

    摘要 : Computational studies introduce an integral approach for finding greener methods through testing solvents for reactions and extractions. Lesinurad is a novel selective uric acid reabsorption inhibitor prescribed for the treatment ... 展开
    关键词 : Lesinurad   BPB   Computational   Green   PERFORMANCE  

    [期刊]   Abhishek Abhishek   《Current opinion in rheumatology》    2018年30卷2期      共6页
    摘要 : Purpose of review To discuss recent studies of lesinurad and arhalofenate. Recent findings Lesinurad acts by blocking urate reabsorption channels URAT-1 and OAT-4. It has urate-lowering effect when used alone and in combination wi... 展开
    关键词 : arhalofenate   gout   lesinurad   uricosuric drugs  

    摘要 : Aim: To estimate budget impact of adopting lesinurad as add-on to allopurinol for urate-lowering therapy in gout. Methods: A budget impact model was developed for a US payer perspective, using a Markov model to estimate costs, sur... 展开
    关键词 : allopurinol   budget impact   gout   lesinurad  

    摘要 : In order to systematically explore and understand the structure-activity relationship (SAR) of a lesinurad-based hit (1c) derived from the replacement of the S atom in lesinurad with CH2, 18 compounds (1a-1r) were designed, synthe... 展开

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